The understanding of human central nervous system (CNS) depends on knowledge of its wiring. However, there are still gaps in our understanding of its wiring due to technical difficulties. While some information is com- ing out from human experiments, medical research is lacking of simulation models to put current findings together to obtain the global picture and to predict hypotheses to lead future experiments. Agent-based modeling and simulation (ABMS) is a strong candidate for the simulation model. In this position paper, we discuss the current status of neural wiring and ABMS in biological systems. In particular, the paper discusses that the ABMS context provides features that require for exploration of wiring of biological neural networks.